Affinity therapeutics. 1. Selective incorporation of 2-thiouracil derivatives in murine melanomas. Cytostatic activity of 2-thiouracil arotinoids, 2-thiouracil retinoids, arotinoids, and retinoids
- 1 August 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (8) , 956-960
- https://doi.org/10.1021/jm00350a014
Abstract
The incorporation of 2-[35S]thiouracil and 2 of its derivatives into murine melanomas [S91 aND Harding Passey], in vivo, was studied. 2-Thiouracil has a marked affinity for melanin-producing tissue and an affinity for such tissue could be sustained by 5-substituted 2-thiouracils. A series of derivatives of arotinoids and retinoids, with or without a 2-thiouracil group as a potential carrier to obtain affinity for melanomas, was examined for cytostatic activity, in vitro. None of these showed significant activity against murine melanomas.This publication has 1 reference indexed in Scilit:
- A new melanoma seeker for possible clinical use: Selective accumulation of radiolabelled thiouracilBritish Journal of Cancer, 1982