Therapy of complex I deficiency: Peripheral neuropathy during dichloroacetate therapy
- 1 November 1995
- journal article
- case report
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 154 (11) , 928-932
- https://doi.org/10.1007/bf01957508
Abstract
DCA lowers the lactate concentration in children with complex I deficiency of the respiratory chain in a dose of 100 mg/kg body weight without clinical benefit. Reversible peripheral polyneuropathy may develop under DCA therapy despite thiamine medication.Keywords
This publication has 21 references indexed in Scilit:
- Findings in muscle in complex I (NADH coenzyme Q reductase) deficiencyAnnals of Neurology, 1988
- Deficiency of subunits of complex I and mitochondrial encephalomyopathyAnnals of Neurology, 1988
- Spatial Localization in NMR Spectroscopy in VivoAnnals of the New York Academy of Sciences, 1987
- Therapy of mitochondrial disordersJournal of Inherited Metabolic Disease, 1987
- Benign Mitochondrial Myopathy with Deficiency of NADH-CoQ Reductase and Cytochrome c OxidaseNeuropediatrics, 1986
- THE CLINICAL FEATURES OF MITOCHONDRIAL MYOPATHYBrain, 1986
- Lactic acidosis in childhood: Part IPediatric Neurology, 1985
- Treatment of chronic congenital lactic acidosis by oral administration of dichloroacetateJournal of Inherited Metabolic Disease, 1985
- NADH-CoQ REDUCTASE DEFICIENT MYOPATHY: SUCCESSFUL TREATMENT WITH RIBOFLAVINThe Lancet, 1983
- AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIAThe Journal of cell biology, 1967