DIPYRIDAMOLE LEVELS IN PLASMA OF MAN AND OTHER SPECIES

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (3) , 495-508
Abstract
Measurements were made of the concentration of dipyridamole [a coronary vasodilator and platelet inhibitor] in the plasma of man, dogs, pigs and pigeons at different times after oral administration of the drug. In dogs and in man, there was considerable variation in the plasma levels of the drug in different subjects. Pigs and pigeons had much lower levels of the drug in plasma than did men and dogs given comparable doses. After i.v. injection of dipyridamole to pigs, a large proportion of the drug appeared to leave the plasma almost immediately. Subsequently the half-life of the drug remaining in the plasma was quite similar to that previously reported in man. The administration of aspirin with dipyridamole sometimes caused higher blood levels of the drug in dogs, man and pigs, but the effects were small. The wide variations in plasma drug levels seen indicate that in future human or experimental trials designed to evaluate the antithrombotic effect of dipyridamole, plasma levels of the drug should be routinely monitored.