Antibacterial Activity of Venom Alkaloids from the Imported Fire Ant, Solenopsis invicta Buren 1

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Abstract
The antibacterial properties of synthetic fire ant venom alkaloids were tested by disc-diffusion procedures against a variety of bacteria and by doubling concentrations in broth cultures of Staphylococcus aureus and Escherichia coli . Gram-positive bacteria were inhibited by lower concentrations of trans -2-methyl-6- n -undecylpiperidine, trans -2-methyl-6- n -tridecylpiperidine, and trans -2-methyl-6- n -pentadecylpiperidine than were gram-negative bacteria. A fourth alkaloid, trans -2-methyl-6-( cis -6-pentadecenyl)piperidine, which was available in minute quantity and was tested by disc-diffusion only, was ineffective against all organisms.