The Resistance of Mice to Myositis and Central Nervous System Infection Following Immunization with GDVII Mouse Encephalomyelitis Virus

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Abstract
Summary: Following immunization of mice by the intraperitoneal route with active GDVII mouse encaphalomyelitis virus, a marked resistance to myositis and local virus multiplication was obtained against subsequent intramuscular challenge of a standard dose of GDVII virus. In addition, there was no invasion of the central nervous system as evidenced by the absence of signs of disease and histologic changes, and the failure to recover active virus from the spinal cords and brains of mice so challenged. Direct intracerebral challenge of a limited number of mice indicated that an immunity was also established in the central nervous system. However, since small amounts of virus were recovered from the central nervous system tissues of some of the immunized mice at the time of challenge, the occurrence of interference cannot be excluded. Immunization by the subcutaneous and intraperitoneal route also led to the development of complement fixing and neutralizing antibodies in considerable concentrations.