Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives
- 1 March 1999
- journal article
- research article
- Published by Wiley in Archiv der Pharmazie
- Vol. 332 (2) , 50-54
- https://doi.org/10.1002/(sici)1521-4184(19993)332:2<50::aid-ardp50>3.0.co;2-s
Abstract
Several new 3‐(isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.Keywords
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