Hypoxanthine and McArdle disease: A clue to metabolic stress in the working forearm
- 1 March 1983
- journal article
- case report
- Published by Wiley in Muscle & Nerve
- Vol. 6 (3) , 204-206
- https://doi.org/10.1002/mus.880060307
Abstract
Forearm exercise in a patient with myophosphorylase deficiency resulted in abnormally high levels of hypoxanthine in the venous blood. The post‐exercise hypoxanthine response may reflect ATP depletion in the muscle and provides a useful screening test in muscle diseases with abnormal energy metabolism.Keywords
This publication has 7 references indexed in Scilit:
- Forearm exercise increases plasma hypoxanthine.Journal of Neurology, Neurosurgery & Psychiatry, 1982
- Hypoxanthine production by ischemic heart demonstrated by high pressure liquid chromatography of blood purine nucleosides and oxypurinesClinica Chimica Acta; International Journal of Clinical Chemistry, 1981
- Examination of a Case of Suspected McArdle's Syndrome by31P Nuclear Magnetic ResonanceNew England Journal of Medicine, 1981
- Purine metabolism during strenuous muscular exercise in manMetabolism, 1980
- Simultaneous analysis of ATP, ADP, AMP, and other purines in human erythrocytes by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1980
- Adenine nucleotide and IMP contents of the quadriceps muscle in man after exercisePflügers Archiv - European Journal of Physiology, 1978
- Contracture in McArdle's DiseaseArchives of Neurology, 1965