Inhibition of angiogenesis and murine tumour growth by laminarin sulphate
Open Access
- 1 May 1996
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 73 (10) , 1183-1186
- https://doi.org/10.1038/bjc.1996.228
Abstract
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).Keywords
This publication has 23 references indexed in Scilit:
- Current approaches to targeting cancer using antiangiogenesis therapiesCancer Treatment Reviews, 1994
- Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of CancersJNCI Journal of the National Cancer Institute, 1994
- Administration of Pentosan Polysulfate to Patients With Human Immunodeficiency Virus-Associated Kaposi's SarcomaJNCI Journal of the National Cancer Institute, 1993
- HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell LineJournal of Investigative Dermatology, 1992
- Inhibition by Pentosan Polysulfate (PPS) of Heparin-Binding Growth Factors Released From Tumor Cells and Blockage by PPS of Tumor Growth in AnimalsJNCI Journal of the National Cancer Institute, 1992
- A Simple Method for Shell‐less Cultivation of Chick EmbryosBasic & Clinical Pharmacology & Toxicology, 1989
- Angiogenic FactorsScience, 1987
- A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin FragmentScience, 1985
- Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan onlyThe British Journal of Radiology, 1985
- Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of CortisoneScience, 1983