An Efficient Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid. (Baclofen)
- 1 June 1995
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 25 (12) , 1777-1782
- https://doi.org/10.1080/00397919508015419
Abstract
A new preparation of baclofen is proposed. The key step involved a regioselective ring opening of 2-phenylaziridine with allylmagnesium bromide. Further oxydation of the side chain give access to 4-phenyl-pyrrolidin-2-one and to baclofen.Keywords
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