Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy.
Open Access
- 1 November 1993
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 56 (11) , 1213-1216
- https://doi.org/10.1136/jnnp.56.11.1213
Abstract
The efficacy of intermittent high-dose vitamin C therapy was evaluated in seven patients with HTLV-I-associated myelopathy (HAM). All HAM patients responded well to this therapy without serious side effects. Grade of disability score improved at 9.7 (SD 5.8) months after the therapy from 7.1 (3.3) to 3.6 (2.0) (p < 0.01). Serum immunosuppressive acidic protein was elevated before and decreased after the therapy from 747 (316) to 398 (86) micrograms/ml (p < 0.05), suggesting favourable immunomodulatory action of vitamin C therapy in HAM patients.Keywords
This publication has 13 references indexed in Scilit:
- Dendritic Cells from Patients with Tropical Spastic Paraparesis Are Infected with HTLV-1 and Stimulate Autologous Lymphocyte ProliferationAIDS Research and Human Retroviruses, 1992
- Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.Proceedings of the National Academy of Sciences, 1990
- In vitro modulation of lymphocyte proliferation by prednisolone and interferon-α in patients with HTLV-I-associated myelopathy (HAM)Journal of Neuroimmunology, 1989
- Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV‐I‐associated myelopathyNeurology, 1988
- Intrathecal synthesis of immunosuppressive acidic protein (IAP) in patients with multiple sclerosis and other inflammatory neurological diseasesJournal of the Neurological Sciences, 1988
- Clinical Electrophysiologic Studies of HTLV-I-Associated MyelopathyArchives of Neurology, 1987
- Significant increase in immunosuppressive acidic protein (IAP) in serum of patients with multiple sclerosis and other inflammatory neurological disordersJournal of the Neurological Sciences, 1986
- HTLV-I ASSOCIATED MYELOPATHY, A NEW CLINICAL ENTITYThe Lancet, 1986
- ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESISPublished by Elsevier ,1985
- Vitamin C in the treatment of acquired immune deficiency syndrome (AIDS)Medical Hypotheses, 1984