Normal Integrated Concentration of Aldosterone and Plasma Renin Activity: Effect of Age*

Abstract
The integrated concentration of aldosterone (IC-ALDO) and PRA (IC-PRA) was studied in 78 normal subjects ranging in age from 9–50 yr. Whereas the IC-ALDO to IC-PRA were found to decrease with age, the ratio of IC-ALDO to IC-PRA was not affected by age. A significant lowering of the normal range and variance was achieved by measuring the 24–h integrated concentration instead of the concentration in discrete samples.

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