Abstract
The peculiar distribution of presenile (45-64) death rates from vascular lesions affecting the central nervous system (CNS) in the United States is epidemiologically discussed. Nutritional factors are suggested to explain the high incidence of such lesions in the Southeastern states, especially in Negroes. In the Southeast, where there are more people of low income than in the Northeast, the prevailing diet is of cereals, lacking in vegetables, fruit, meat and milk. Consequently, some vitamin deficiency should result, especially of A,C, and B-complex as well as calcium deficiency. These nutritional deficiencies might also be considered as an etiological factor in the high incidence of vascular lesions affecting the CNS in Japan.

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