Proliferative Epithelial Lesions of the Urinary Bladder of Nonhuman Primates Infected With Schistosoma haematobium2

Publisher Website
Google Scholar
Abstract
Lesions with the morphologic characteristics of papillary transitional cell carcinomas of the urinary bladder were found in a talapoin monkey and a capuchin monkey infected with Schistosoma haematobium, and a papilloma of the ureter was found in an infected African baboon. Marked proliferation and squamous metaplasia of the bladder epithelium were seen in 2 squirrel monkeys and in 1 capuchin monkey. These lesions were seen 5–24 months after infection of the monkeys. Epithelial proliferation was topographically related to the presence of S. haematobium eggs in the lamina propria of the bladder. This and the absence of reports of spontaneous bladder cancer in monkeys suggest that the proliferative lesions were caused by the schistosome infection. The relatively small number of capuchin, talapoin, and squirrel monkeys at risk during the period in which tumors developed suggests that infected animals of these species may offer useful models for the study of bladder cancer.

This publication has 0 references indexed in Scilit: