Intermittent Treatment With Streptokinase in Arterial Disease of the Limbs

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Abstract
Patients (62) with arterial disease of the lower limbs were treated with streptokinase by intermittent administration. All patients had experienced recent aggravation of their arterial disease, and 22 had thrombolysis confirmed by arteriography. In 20 cases clinical study showed repermeation- in 8 cases during the 1st perfusion and in 8 cases during the 3rd perfusion. During the 1st perfusion the fall in fibrogen was significantly greater in the 8 patients with thrombolysis. The 3rd perfusion corresponded to a new phase of fibrinogenolysis. The possibility of the relationship between plasminemia and thrombolysis is supported, and the limits of the classic theory of Sherry, Fletcher and Alkjaersig are emphasized. Permitting phases of repeated but limited plasminemia, the interruption method used here is a compromise between risk of hemorrhage and efficacy of treatment at low dosage.