Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease
- 11 June 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 148 (3676) , 1477-1479
- https://doi.org/10.1126/science.148.3676.1477
Abstract
Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.Keywords
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