Head-to-Tail Oxime Cyclization of Oligodeoxynucleotides for the Efficient Synthesis of Circular DNA Analogues
- 1 October 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (22) , 8708-8710
- https://doi.org/10.1021/jo035064h
Abstract
A convenient strategy for the synthesis of the analogue of cyclic oligodeoxyribonucleotides is presented. The cyclization of the oligonucleotide was accomplished through intramolecular oxime bond formation between a 5‘-oxyamine moiety and a 3‘-aldehydic group.Keywords
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