T Cell Regulation of the Antibody Response to Bacterial Polysaccharide Antigens: An Examination of Some General Characteristics and Their Implications
- 1 June 1992
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 165 (Supplement) , S44-S48
- https://doi.org/10.1093/infdis/165-supplement_1-s44
Abstract
The characteristics of thymus-derived (T) lymphocytes that regulate the magnitude of the antibody response to the capsular polysaccharide antigen of type III Streptococcus pneumoniae are considered within the context of a general homeostatic model for controlling the antibody response to microbial antigens of medical importance. Some experimental approaches are described in which the activities of such regulatory T cells are modulated to provide an increase in the development of host immunity, to improve the immunogenicity of poorly immunogenic antigens, or to eliminate the inhibitory effects of suppressor T cells.Keywords
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