Abnormal Glucose Metabolism in Murine Cytomegalovirus (MCMV)-Infected Mice

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Abstract
Five strains of male and female mice were infected with salivary gland-passaged murine cytomegalovirus (SG-MCMV) i.p. Although none of them became hyperglycemic, 13-30% of BALB/c male and female, ICR/Slc male and female and C57BL/6J male mice had abnormal values in glucose tolerance tests (GTT) 14 to 30 day post infection. Serum insulin levels in BALB/c male mice were low and infective virus was detected in the pancreas during the acute phase of infection. Histopathology showed mild edematous changes with inflammatory cell infiltrations in the pancreas. Viral antigen was located in acinar cells and occasionally in .beta. cells by an immunofluorescence test.