CRYSTALLOID VERSUS COLLOID HEMODILUTION IN MAN

  • 1 January 1976
    • journal article
    • research article
    • Vol. 142  (4) , 506-512
Abstract
The effects of intraoperative prebleeding and hemodilution with lactated Ringer''s solution on hemodynamics, O2 transport and lung water were studied in 4 patients undergoing extensive surgical procedures. The results were contrasted with those previously obtained from hemodilution of a group of patients with Plasmanate. The mean volumes bled were 1950 ml in the lactated Ringer''s solution group and 1697 ml in the Plasmanate group. The posthemodilution hematocrit values were 26% and 25%, respectively. Cardiac output increased to only 115% of the base line in the lactated Ringer''s solution group but to 161% in the Plasmanate group. Systemic O2 transport was reduced to 80.0% in the lactated Ringer''s solution group, while in the Plasmanate group, it rose to 109.7%. The lung water and alveolar arterial O2 gradients were increased to 134 and 112% in the lactated Ringer''s solution group, but in the Plasmanate group, the lung water was reduced to 82% and the arterial alveolar O2 gradient was reduced to 75%. In these selected patients, hemodilution was well tolerated. Plasmanate hemodilution resulted in better compensatory changes than did hemodilution with lactated Ringer''s solution in terms of O2 transport and changes in lung water.

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