New Synthesis of 1,4 Benzodiazepine-2,5-diones by Means of HCL Gas Catalyst
- 1 August 1993
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 23 (16) , 2265-2272
- https://doi.org/10.1080/00397919308013783
Abstract
A new synthesis of 1,4- benzodiazepinediones 4 , particularly 1,4-dihydro1H-1,4-benzodiazepine-2,5-dione, 4c key intermediate of metabolites cyclopenin 9 , cyclopenol 10 , cyclopeptine 11 and dehydrocyclopeptine 12 , was achieved by action of dry HCl gas in DMF on compound 3 prepared from anthranilic acid derivative 1 and amino ester 2 .Keywords
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