Antimicrobial-susceptibility testing of rapidly growing pathogenic bacteria

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Abstract
The ‘Comparative’, Stokes, Ericsson (ICS), and Kirby–Bauer (FDA) disc-diffusion methods of antimicrobial-susceptibility testing were compared. There was little difference between the performances of the four methods when each was carried out correctly. The Comparative and Ericsson methods showed slightly better reproducibility of zone sizes than did the other methods. For pseudomonads, variations of zone sizes in replicate tests led to differences of interpretation more often with the Ericsson and Kirby-Bauer methods. For other organisms this occurred somewhat more often with the Stokes method. Major differences of the interpretation obtained by different methods occurred in 7.7% of all comparisons.

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