Slow Conduction and Reentry in the Ventricular Conducting System

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Abstract
Depression of excitability and responsiveness provoked by the action of high K+ and epinephrine on short bundles of excised canine Purkinje fibers yields reentrant excitation. An impulse entering a depressed area undergoes marked slowing of conduction; the impulse then may continue forward while also returning through the pathway by which the initiating impulse entered the depressed area. The impulse may be delayed or blocked in either the forward or the retrograde direction. The reentrant excitation can occur in the absence of premature excitation. Various methods of depression of excitability produce return extrasystoles in Purkinje fibers. The common factor is very slow conduction which depends upon the abolition of the fast upstroke and the appearance of a low-voltage, slowly propagated action potential that is readily blocked.