Altered amounts of hemoglobin synthesis in livers of dystrophic hamsters

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Abstract
In liver supernatant similar amounts of leucine are incorporated into proteins of normal and dystrophic hamsters. However, using a dual labeling technique, a protein fraction was detected which showed different levels of leucine incorporation between normal and dystrophic animals in an age-dependent fashion. The major protein in this fraction co-migrated with Hb or its subunits under various conditions of polyacrylamide gel electrophoresis. In animals younger than 3 days there was more synthesis of this protein fraction in dystrophic animals animals, while at 6 days there was considerably less synthesis of this protein. These changes were paralleled by differences in the number of erythroid foci in histological sections of the livers. There was no evidence for structurally altered Hb in dystrophic hamsters. The significance of this finding and its possible relation to the dystrophy process are not known.

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