Investigation of the Anti-Tumour Action of Eupatoriopicrin Against the Lewis Lung Tumour

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Abstract
In this work eupatoriopicrin, the principal sesquiterpene lactone in Eupatorium cannabinum L., was tested for possible cytostatic activity in an experimental solid tumour system of the mouse: the Lewis lung tumour. The tumour cells were transplanted subcutaneously in the left back flank of female C57BL mice. Eupatoriopicrin was administered intraperitoneally as a fine suspension in saline. The animals were treated with the drug at a tumour volume of 500 µl or at an earlier stage, at which no tumour was visible yet. After treatment, progress of tumour growth was measured and compared with a control group. Different doses and dosage schedules were used. Treated animals showed a delay in tumour growth. Repeated administration resulted in a prolonged growth delay.

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