DISTRIBUTION OF IGA-1 AND IGA-2 PLASMA-CELLS IN VARIOUS NORMAL HUMAN TISSUES AND IN JEJUNUM OF PLASMA IGA-DEFICIENT PATIENTS
- 1 January 1978
- journal article
- research article
- Vol. 33 (2) , 327-331
Abstract
The distribution of Ig[immunoglobulin]A 1 and IgA 2 plasma cells was studied in normal human tissues. IgA 2 is a minor constituent in peripheral lymph nodes and in serum and bone marrow plasma cells. An increased proportion of IgA 2 plasma cells was observed in gastric and intestinal mucosa, bronchial mucosa, salivary and mammary glands. Tonsils and mesenteric lymph nodes exhibit values intermediate between those of central and peripheral lymphoid systems. In patients with plasma IgA-deficiency, IgA 2 was the predominant intestinal IgA plasma cells. This may explain the frequent association of an asymptomatic condition and plasma IgA deficiency.This publication has 8 references indexed in Scilit:
- INTESTINAL IMMUNOCYTES AND IMMUNOGLOBULINS IN PATIENTS WITH PRIMARY HYPOGAMMAGLOBULINEMIA - STUDY OF 26 CASES1977
- PLASMATIC INCREASE OF MONOMERIC AND DIMERIC IMMUNOGLOBULIN-A IN ALCOHOLIC CIRRHOSIS1976
- DICHOTOMY BETWEEN IMMUNOGLOBULIN SYNTHESIS BY CELLS IN GUT AND BLOOD OF PATIENTS WITH HYPOGAMMAGLOBULINqMIAThe Lancet, 1975
- Immunohistochemical Characterization of Local Immunoglobulin Formation in Ulcerative ColitisGastroenterology, 1974
- Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique.1974
- Distribution of IgA Subclasses in Sera and Bone Marrow Plasma Cells of 21 Normal IndividualsPublished by Springer Nature ,1974
- A SUBCLASS OF HUMAN γA-GLOBULINS (γA2) WHICH LACKS THE DISULFIDE BONDS LINKING HEAVY AND LIGHT CHAINSThe Journal of Experimental Medicine, 1968
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965