Antiviral Activity of an Ether-Extracted Nonviable Preparation of Brucella abortus
- 1 December 1974
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 10 (6) , 1202-1206
- https://doi.org/10.1128/iai.10.6.1202-1206.1974
Abstract
Extraction of living Brucella abortus (strain 456) with aqueous ether yielded a nonviable, insoluble residue (Bru-Pel). When injected into mice, Bru-Pel was an effective, nontoxic interferon stimulus. Mice pretreated with Bru-Pel were protected against challenge with otherwise lethal doses of Semliki Forest virus. Significant protection was afforded when Bru-Pel was given as many as 7 days before virus challenge. Evidence is presented dealing with the complex nature of Bru-Pel and with the possibility that the antiviral activity of Bru-Pel may be associated not only with the production of interferon, but with a general increase in the level of nonspecific resistance in animals.Keywords
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