Single‐chain antibodies for the conformation‐specific blockade of activated platelet integrin αIIbβ3 designed by subtractive selection from naïve human phage libraries
Open Access
- 16 September 2004
- journal article
- fj express-summarie
- Published by Wiley in The FASEB Journal
- Vol. 18 (14) , 1704-1706
- https://doi.org/10.1096/fj.04-1513fje
Abstract
Binding of fibrinogen to platelet integrin αIIbβ3 mediates platelet aggregation, and thus inhibition of αIIbβ3 represents a powerful therapeutic strategy in cardiovascular medicine. However, the curr...Keywords
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