Creatinine excretion in the squirrel monkey

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Abstract
Stop-flow studies indicate that exogenous creatinine is secreted at approximately the same site in the proximal tubule as [para-amino hippurate] PAH. When PAH secretion was increased from well below saturation of the transport system to [transport maximum] Tm, creatine secretion was reduced somewhat, suggesting a sharing of the organic acid transport system. This was confirmed by free-flow experiments employing PAH loading. When PAH load/Tm was increased from ca. 0.5 to over 1.0, ongoing creatinine secretion was depressed. Finally, the use of probenecid also partially blocked creatinine secretion. These 3 lines of evidence suggested that under the conditions of the experiments, creatinine was suggested in part by the organic acid mechanism. On the other hand, Darstine and quinine sulfate, known competitors of the organic base secretory system, selectively blocked a moiety of creatinine secretion while not affecting PAH secretion, accounting for a substantial part of the total transport process. EDTA which was designated a "third" tubular secretory mechanism in the rat, appears to be slightly secreted by the monkey kidney, but does not significantly influence creatinine secretion.

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