Isoniazid effects on choreiform movement and on GABA, HVA and 5-HIAA in CSF
- 1 February 1983
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 67 (2) , 124-127
- https://doi.org/10.1111/j.1600-0404.1983.tb04554.x
Abstract
Isoniazid was administered in 4-week open trial in patients with choreiform movement. Gamma-aminobutyric acid (GABA), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in CSF were measured before and after treatment. Isoniazid did not improve choreiform movement. CSF GABA levels were significantly increased after treatment, but HVA and 5-HIAA levels were not significantly altered. The findings suggest that isoniazid influenced brain GABA metabolism but did not influence dopamine and serotonin metabolism in patients with chorieform movement.Keywords
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