Clioquinol Intoxication Occurring in the Treatment of Acrodermatitis Enteropathica with Reference to SMON Outside of Japan

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Abstract
Many past cases of SMON have occurred in Japan but since 1975 no new cases have been reported. One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol. Acrodermatitis enteropathica with SMON almost always has a high occurrence of visual impairment, but other sensory disturbances are slight or absent, while common adult SMON is just the opposite. We do not know why these differences occur.

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  • CORRECTION
    Japanese Journal of Medical Science and Biology, 1975