Poor Mental Development in Patients With Tuberous Sclerosis Complex
Open Access
- 1 March 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (3) , 379-384
- https://doi.org/10.1001/archneur.55.3.379
Abstract
TUBEROUS SCLEROSIS complex (TSC) is characterized pathologically as hamartias (nongrowing focal congenital anomalies), hamartomas (benign growths), and true neoplasms1 in various organs, such as brain, skin, kidneys, liver, and heart.2 The predominant neurological manifestations of TSC are seizures, mental retardation, and behavioral abnormalities, with seizures being the most common initial sign of central nervous system involvement.3 Poorly controlled seizures as well as certain types of seizures, eg, infantile spasms, are considered to be indicative of poor overall neurodevelopmental prognosis.3,4 Some of the other alleged risk factors include male sex5 and exposure to diphtheria, tetanus, and pertussis (DTP) immunizations.6Keywords
This publication has 2 references indexed in Scilit:
- Phenotypes of the Tuberous Sclerosis Complex with a Revision of Diagnostic CriteriaAnnals of the New York Academy of Sciences, 1991
- Adverse Effects of Pertussis and Rubella VaccinesPublished by The National Academies Press ,1991