IMMUNOLOGICAL DISSECTION OF RAT PREGNANCY - STUDY OF MODE OF ACTION OF ANTISERA TO LUTEINIZING-HORMONE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (2) , 326-333
Abstract
The sensitivity of rat pregnancy to luteinizing hormone (LH) depletion on days 7-12 (day 1 = day of insemination) was investigated by i.p. administration of a single injection of various doses of an anti-bovine LH rabbit serum on the day in question. Day 11 was apparently the most susceptible time for this kind of intervention. The fate of anti-LH antibodies in the recipients was followed in the serum and in various organs of the treated animals. Serological analysis revealed persistence of free antibodies to LH in the serum as late as 48 h after injection. Immunofluorescence studies showed immune complex deposition in the kidney glomerula.