An Intramolecular Diels-alder Reaction of a Z-Diene. Generation Of The Chiral Isoindolone Nucleus Of Cytochalasin C.1
- 1 September 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (11) , 1297-1314
- https://doi.org/10.1080/00397918608056378
Abstract
Aldol/elimination reactions of ß-ketoamides with methyl glyoxylate result in highly selective production of Z-α,ß-unsaturated amides. An intramolecular Diels-Alder reaction of a triply activated dienophile derived from chiral dienylamine 7ZE stereospecifically affords chiral bicyclic lactam 11 at room temperature.Keywords
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