Identification of a third nuclear protein-coding gene required specifically for posttranscriptional expression of the mitochondrial COX3 gene is Saccharomyces cerevisiae
Open Access
- 29 February 1988
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 170 (3) , 1399-1402
- https://doi.org/10.1128/jb.170.3.1399-1402.1988
Abstract
A third nuclear protein-coding gene termed PET122 has been shown to be required for a post-transcriptional step in expression of the mitochondrial COX3 gene is Saccharomyces cerevisiae. pet122 mutants fail to produce cytochrome c oxidase subunit III, which is the polypeptide product of the COX3 gene, but produce normal amounts of mature COX3 mRNA. A strain bearing the pet122-1 allele is amber suppressible and correctly processes the 5' end of COX3 mRNA. Therefore, the PET122 gene product is a protein required for the expression of COX3 at some step after transcription and 5'-end processing of its transcript.This publication has 29 references indexed in Scilit:
- Nuclear functions required for cytochrome c oxidase biogenesis in Saccharomyces cerevisiae: multiple trans-acting nuclear genes exert specific effects on expression of each of the cytochrome c oxidase subunits encoded on mitochondrial DNACurrent Genetics, 1987
- Nuclear gene products required for translation of specific mitochondrially coded mRNAs in yeastTrends in Genetics, 1986
- Two yeast nuclear genes, CBS1 and CBS2, are required for translation of mitochondrial transcripts bearing the 5?-untranslated COB leaderCurrent Genetics, 1986
- GENETICS OF MITOCHONDRIAL BIOGENESISAnnual Review of Biochemistry, 1986
- Mitochondrial suppression of a yeast nuclear mutation which affects the translation of the mitochondrial apocytochrome b transcriptCurrent Genetics, 1985
- A nuclear mutation that post-transcriptionally blocks accumulation of a yeast mitochondrial gene product can be suppressed by a mitochondrial gene rearrangementJournal of Molecular Biology, 1984
- A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNAScience, 1984
- Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit ICell, 1983
- Assembly of the mitochondrial membrane system. Analysis of the nucleotide sequence and transcripts in the oxi1 region of yeast mitochondrial DNA.Journal of Biological Chemistry, 1981
- Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.Journal of Biological Chemistry, 1980