Thyroid Stimulatory Action of (Z)-Guggulsterone: Mechanism of Action
- 1 August 1988
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 54 (04) , 271-277
- https://doi.org/10.1055/s-2006-962431
Abstract
(Z)-Guggulsterone, a ketosteroid isolated from the oleoresin of the dry exudate of Commiphora mukul, has been shown to stimulate the thyroid function in rats. This drug is now shown to counteract the thyroid-suppressant activity of a known thyroid inhibitor (carbimazole). This set of observations distinguishes the thyroid stimulatory action of (Z)-guggulsterone from that of the thyroid stimulatory hormone (TSH) of pituitary origin. It is, therefore, concluded that the action of (Z)-guggulsterone is not mediated by the pituitary.This publication has 5 references indexed in Scilit:
- Structure-Activity Relationships of Inhibition of Hepatic Monodeiodination of Thyroxine to 3,5,3′-Triiodothyronine by Thiouracil and Related Compounds*Endocrinology, 1982
- The Irreversible Inactivation of Thyroid Peroxidase by Methylmercaptoimidazole, Thiouracil, and Propylthiouracil in Vitro and Its Relationship to in Vivo Findings*Endocrinology, 1978
- MITOTIC RATE OF RATS THYROID-GLAND DURING HYPERTROPHY INDUCED BY AN ANTI-THYROID AGENT (CARBIMAZOLE)1978
- Effect of Antithyroid Agents 6-Propyl-2-Thiouracil and l-Methyl-2-Mercaptoimidazole on Human Thyroid Iodide PeroxidaseJournal of Clinical Endocrinology & Metabolism, 1976
- THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBINThe Journal of general physiology, 1938