TUNICAMYCIN INHIBITS GLCNAC-LIPID FORMATION IN PLANTS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 252  (21) , 7431-7433
Abstract
Previous studies showed that particulate extracts from cotton fibers and mung bean seedlings catalyze the transfer of mannose from GDP-[14C]mannose and GlcNAc from UDP-[3H]GlcNAc into lipid-linked saccharides. Concentrations of tunicamycin [glycoside antibiotic from Streptomyces lysosuperificus] of 5 .mu.g/ml or higher inhibit the incorporation of GlcNAc into GlcNAc-pyrophosphoryl-polyprenol but this antibiotic, even at 500 .mu.g/ml, had no effect on the synthesis of mannosyl-phosphoryldolichol. Tunicamycin also caused a slight inhibition in the incorporation of mannose into lipid-linked oligosaccharides. The concentration of tunicamycin necessary for inhibition was dependent on the amount of particulate enzyme in the incubations.

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