Amphotericin B Induction of Sensitivity to Adriamycin, 1,3-bis (2-Chloroethyl)-1-Nitrosourea (BCNU) plus Cyclophosphamide in Human Neoplasia

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Abstract
Patients (7) with metastatic tumors resistant to therapy with adriamycin, BCNU, plus cyclophosphamide received the same chemotherapy combined with amphotericin B. One complete response (acute myelomonocytic leukemia), 2 partial responses (carcinoma of the breast and multiple myeloma), and 1 case with objective improvement (carcinoma of the breast) were observed in 7 evaluable trials. Myelosuppression was not consistently changed by addition of amphotericin B. Fever and chills were common after amphotericin B. Bronchospasm and hypotension occurred twice. Amphotericin B reverses resistance to adriamycin-containing chemotherapy regimens in some patients.