Oxygen-Derived Free-Radical Scavengers Prolong Survival in Colonic Cancer
- 1 January 1992
- journal article
- clinical trial
- Published by S. Karger AG in Chemotherapy
- Vol. 38 (2) , 127-134
- https://doi.org/10.1159/000238952
Abstract
The influence of scavengers of oxygen-derived free radicals on survival in colonic cancer was studied. Following curative surgery for carcinoma of the sigmoid colon at Dukes’ stage C, 198 patients making an uneventful recovery from surgery were randomized to the control group or to receive allopurinol (50 mg orally 4 times a day) or dimethyl sulphoxide (DMSO, 500 mg orally 4 times a day). In 144 fully evaluable patients who were studied for 5 years, allopurinol and DMSO incurred a significant (pKeywords
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