Background/Aims: The principal aims of the new hemodialysis methods are: a short-time dialysis session, the increase of solute removal, the patient’s well-being and, when possible, the reduction of global costs. Other researchers have experimented the simultaneous use of two hemodialyzers in hemodialysis. We tested a new technique which involves the use of two Cuprophan hemodialyzers in sequence (double filter system: DFS), each one connected separately to fresh dialysate. Methods: We treated 15 large patients with DFS and compared the results with conventional hemodialysis (CHD). Results: Our results showed a significant difference between CHD and DFS in the depuration values. After the first hemodialyzer, modification of pH and electrolytes occurred in the plasma composition. In the second hemodialyzer, urea depuration occured without further significant changes in hydroelectrolytic and acid-basic plasma patterns. The Kt/V increased from 1.10 to 1.29 (18%). Conclusion: Our technique is conceived for the following goal: to increase the diffusion of solution without increasing costs and side effects.