Infectious pancreatic necrosis virus internalization and endocytic organelles in CHSE-214 cells
- 1 January 1992
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 16 (9) , 899-906
- https://doi.org/10.1016/s0309-1651(06)80169-4
Abstract
The early events that take place during the internalization of infectious pancreatic necrosis virus (IPNV) into Chinook salmon embryo cells (CHSE-214) were analyzed ultrastructurally. Endocytic tracers were employed in order to characterize the organization of endocytic organelles in CHSE-214 cells, as well its relation to the IPNV penetration. Results demonstrate that IPNV appear internalized within vesicular compartments which are located peripherally in CHSE-214 cells. Despite the high rate of infectious multiplicity few virus particles were detected inside the cells. Endocytic tracer labelling of tubulovesicular elements and endosomes of host cells showed a well developed endocytic apparatus. Results suggest that endocytosis may be involved during the initiating events in the productive IPNV infection.Keywords
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