Direct determination of nickel in human plasma by Zeeman-corrected atomic absorption spectrometry

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Abstract
A procedure is described for the direct determination of nickel in human plasma in which the samples are diluted before quantitation by means of Zeeman-corrected atomic absorption spectrometry. The limit of detection is 0.09 µg l–1 and the limit of quantitation 0.31 µg l–1. For healthy, unexposed subjects, the mean value of nickel in plasma was found to be 0.65 ± 0.35 µg l–1(n= 6)(range 1.28 ± 0.02 to 0.32 ± 0.05 µg l–1). The method fails to give the recommended value of 1.8 ± 0.6 µg l–1 for nickel in the NBS reference material RM 8419, bovine serum. Instead the concentration was found to be 0.48 ± 0.04 µg l–1(n= 3). It is suggested that the recommended value may be in error.

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