Lithium side effects in relation to dose and to levels and gradients of lithium in plasma

Publisher Website
Google Scholar
Abstract
The relation between Li dose, Li concentrations and Li gradients in plasma and the side effects tremor, nausea, abdominal pains and loose bowels was studied in 19 subjects [17 patients and 2 healthy volunteers]. Rapidly dissolving lithium carbonate tablets were used. Tremor was related to higher doses, to higher concentrations, and to higher gradients of Li in plasma. Nausea was related to higher gradients. Abdominal pain and loose bowels showed no relation to doses, levels or gradients. Concentrations of Li were dose-dependent, while gradients were relatively independent of dose.