In-vivo- und In-vitro-Suppression der Lymphozytenfunktion bei Nebenhöhlenmykosen

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Abstract
In about 10% of patients operated on a chronic sinusitis, an aspergilloma is found in the paranasal sinus. To detect possible underlying immunodeficiencies. patients with aspergilloma were subjected to an immunological screening programme. The data were compared with those of patients suffering from nonmycotic chronic sinusitis and healthy controls. Totale lymphocyte counts and immunological levels were normal in both groups of sinusitis. Leukocyte subset anlyses by membrane fluorescence revealed a significant decrease of CD11 + cells, i.e. macrophages/monocytes and NK cells, in both types of sinusitis. Furthermore, a markedly enchanced frequency of CD25 + cells, i.e. IL 2-receptor bearing cells, was observed in patients with aspergillima. Peripheral blood lymphocytes of both groups of patients showed a significant reduction in the proliferative response to both T and B-cell mitogens, the values for the mitogens ConA and PWM being significantly lower in aspergilloma patients than in those with non-mucotic sinustitis. This lack of lymphocyte stimulation in the aspergilloma group was also manifest in skin test to recall antigens. These first data suggest an immunodeficiency in association with chronic sinusitis caused by Aspergillus fumigatus. Further studies are needed to clarify if this defect is cause or result of the mycotic infection.

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