HLA-D associated alloantisera react with molecules similar to Ia antigens.

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Abstract
Two human alloantisera specific to bone marrow-derived (B) cells precipitated polypeptide chains of 29,000 and 34,000 daltons from human lymphoblastoid B cell lines. These molecules are similar to murine Ia [immune response-associated] antigens and are precipitated by a rabbit B-cell specific heteroantiserum. Since the alloantisera are thought to recognize determinants coded by HLA-D or closely linked loci, these B-cell specific alloantigens are probably the human counterpart of the mouse Ia antigens and may be the products of HLA-D.