HEMATURIA FROM SULFATHIAZOLE THERAPY IN PNEUMONIA

3 August 1940

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 115 (5) , 362-363
https://doi.org/10.1001/jama.1940.72810310003007a

Abstract

The tendency of sulfapyridine to form urinary crystals resulting in hematuria and even obstruction is by this time well known. Gross, Cooper and Scott¹have collected from the literature thirty-six cases of gross hematuria, with seven in which uroliths were specifically mentioned, complete bilateral ureteral block being disclosed at autopsy in one instance.²Plummer and McLellan³have reported two cases of unilateral calculus formation, one of which was fatal. Arnett, Shoup and Henry⁴have reported a case of bilateral ureteral obstruction with recovery. The fact that similar complications can arise in the course of sulfathiazole therapy is now beginning to be recognized. Gross, Cooper and Scott¹have demonstrated concretions in the kidneys of rats receiving sulfathiazole, and Pepper and Horack⁵reported the death of a 77 year old pneumonia patient who developed hematuria and oliguria while on sulfathiazole therapy. At autopsy the kidneys were

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