5‐Hydroxytryptamine Amplifies β‐Adrenergic Stimulation of N‐Acetyltransferase Activity in Rat Pinealocytes
- 1 November 1990
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 55 (5) , 1655-1658
- https://doi.org/10.1111/j.1471-4159.1990.tb04952.x
Abstract
In cultured rat pinealocytes .beta.-adrenergic induction of N-acetyltransferase, a key enzyme in the synthesis of melatonin, is amplified by addition of 5-hydroxytryptamine (5-HT) to the culture medium. However, 5-HT when added alone has no effect on enzyme activity. Pharmacological experiments with a range of agonists and antagonists suggest that this action is not mediated by 5-HT1, 5-HT2, 5-HT3, or 5-HT4 receptor subtypes but may involve a site similar to the 5-HT1p receptor described in the enteric nervous system. The potential role of 5-HT in modulating adrenergic stimulation of N-acetyltransferase activity is discussed.Keywords
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