The telomeric PARP, tankyrases, as targets for cancer therapy
Open Access
- 17 January 2006
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 94 (3) , 341-345
- https://doi.org/10.1038/sj.bjc.6602951
Abstract
The requirement for the maintenance of telomeres by telomerase by most cancer cells for continued proliferation is a target in anticancer strategies. Tankyrases are poly(ADP-ribose) polymerases that enhance telomerase access to telomeres. Tankyrase 1 modulates telomerase inhibition in human cancer cells and is reviewed in this report as a potential telomere-directed anticancer target.Keywords
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