Dissolution Kinetics of Some Alkyl Derivatives of Acetaminophen
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 4 (6) , 529-535
- https://doi.org/10.3109/03639047809081824
Abstract
Intrinsic aqueous dissolution rates are shown to be better related to octanol-water partition coefficients than to aqueous solubilities, for six alkyl derivatives of acetaminophen. Aqueous solubilities are shown to relate surprisingly well to partition coefficients, but this is probably due to the very close structural similarity of the compounds investigated. The activation energy of dissolution does not vary greatly with lipophilicity, which suggests that the mechanism of dissolution is the same for all the compounds studied.This publication has 3 references indexed in Scilit:
- Linear free-energy relationship between partition coefficients and the aqueous solubility of organic liquidsThe Journal of Organic Chemistry, 1968
- Some New Amino AlkylphenolsJournal of the American Chemical Society, 1954
- THE RATE OF SOLUTION OF SOLID SUBSTANCES IN THEIR OWN SOLUTIONS.Journal of the American Chemical Society, 1897