Controlled biosynthesis of neoviridogriseins, new homologues of viridogrisein. II. Production, biological properties and structure of neoviridogrisein II.

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Abstract
An isolate of Streptomyces griseoviridus, which produced 3 minor factors in addition to viridogrisein and griseoviridin, was more sensitive to the addition of L-proline than the type culture of S. griseoviridus (NRRL2427). Yield improvement of these minor factors was attempted by the so-called controlled biosynthesis with L-proline. Addition of L-proline increased the production of neoviridogrisein II in which allo-hydroxy-D-proline in viridogrisein was replaced by D-proline.