ADDITION OF CISPLATIN AND BLEOMYCIN TO VINCRISTINE-CARMUSTINE-DOXORUBICIN-PREDNISONE (VBAP) COMBINATION IN THE TREATMENT OF RELAPSING OR RESISTANT MULTIPLE-MYELOMA - A SOUTHWEST-ONCOLOGY-GROUP STUDY

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 68  (3) , 481-485
Abstract
Fifty-five patients with myeloma who had relapsed on or were resistant to melphalan and/or cyclophosphamide with prednisone received vincristine, carmustine, doxorubicin and prednisone (VBAP) plus cisplatin and bleomycin at 21-day intervals. Eighteen (32.7%) patients responded. The response rate was 38.5% (15 responses among 39 patients) in relapsing patients. Three (18.8%) of 16 patients with resistant myeloma responded. Granulocytopenia was the most frequent toxic effect, and was severe in 12 (22%) patients. Severe thrombocytopenia occurred in 7 (13%) patients and severe nausea and vomiting occurred in eight (15%). One patient with previously normal renal function developed renal failure on this regimen. The median survival (100 wk) in those patients responding to treatment was significantly longer than that in patients not responding (25 wk; P = 0.001). VBAP plus cisplatin and bleomycin was at least as effective as VBAP but had greater toxicity, expense, and inconvenience; it therefore is not preferable to VBAP.

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